Viral Hepatitis C: Epidemiology, Pathogenesis, Transmission, And Natural History
- Changing incidence and prevalence of HCV
- Increasing burden of HCV-related liver disease
Latest Updates
- Advances are being made in the realm of treatment, including new short acting Granulocyte Colony Stimulating Factor medications, such as Neupogen (Filgrastim), Zarxio (Filgrastim-sndz), Fulphila (Pegfilgrastim-jmdb), and Leukine (Sargramostim) which have been FDA approved for treatment of severe neutropenia.
- Previously accepted policies due to "radiation phobia" by those in the scientific community were based on a linear-no threshold scale for radiation dose and the link to cancers such as leukemia. These scales continue to be discredited as being magnitudes lower than the observed rates of incidence. In current literature, scientists are challenging the idea that the dose threshold for exposure is as low as we accept right now (~ 100 mSV) and in fact are demonstrating that the increased risk for cancer development amongst individuals exposed to similar doses does not exist until a much higher radiation dose. Scientists will continue to follow this and establish an acceptable recommendations because of the ubiquitous nature of radiation exposure in our medical and industrial lives.
- Patients developing hematopoietic syndrome, or even simply anemia, after significant exposure to radiation requiring blood transfusion are at increased risk of developing Graft-versus-Host disease. Current guidelines state that, when possible, cellular transfusion products (i.e, whole blood, pRBCs) should be irradiated with at least 25 Gy prior to administration. The samples should also undergo leukocyte reduction as well. In situations of mass casualty incidents, guideline therapy may be adjusted based on the supply of blood available against the anticipated need for blood on mass scale.
- Epidemiology of and heritable risk factors for developing addictive disorders
- Dysregulated brain networks and neurochemical systems in several substance and nonsubstance addictions
- Treatment options for substance and nonsubstance addictions
- Updated with 2020 ASAM Practice Guidelines: Opioid Use Disorders
- Nonpharmacologic measures that have the potential to improve outcomes in osteoarthritis include patient education, physical and occupational therapy assessment and interventions, exercise, weight loss, and dietary measures.
- Therapies with potential to prevent or retard the progression of articular cartilage breakdown have received a great deal of attention in recent years, including tetracyclines, protease inhibitors, antiresorptive agents (i.e., bisphosphonates, calcitonin), glycosaminoglycan compounds, growth factors, and cytokine inhibitors.
- In patients with badly damaged knees and hips, total joint replacement is an effective option. Almost all patients experience significant pain relief, and some have improved range of motion. Joint loosening and infection are potential late complications in prosthetic joints but are uncommon.
- 2019 ACR/AF Practice Guidelines: Osteoarthritis of the Hand, Knee, and Hip
- Nonpharmacologic measures that have the potential to improve outcomes in osteoarthritis include patient education, physical and occupational therapy assessment and interventions, exercise, weight loss, and dietary measures.
- Therapies with potential to prevent or retard the progression of articular cartilage breakdown have received a great deal of attention in recent years, including tetracyclines, protease inhibitors, antiresorptive agents (i.e., bisphosphonates, calcitonin), glycosaminoglycan compounds, growth factors, and cytokine inhibitors.
- In patients with badly damaged knees and hips, total joint replacement is an effective option. Almost all patients experience significant pain relief, and some have improved range of motion. Joint loosening and infection are potential late complications in prosthetic joints but are uncommon.
- Nonpharmacologic measures that have the potential to improve outcomes in osteoarthritis include patient education, physical and occupational therapy assessment and interventions, exercise, weight loss, and dietary measures.
- Therapies with potential to prevent or retard the progression of articular cartilage breakdown have received a great deal of attention in recent years, including tetracyclines, protease inhibitors, antiresorptive agents (i.e., bisphosphonates, calcitonin), glycosaminoglycan compounds, growth factors, and cytokine inhibitors.
- In patients with badly damaged knees and hips, total joint replacement is an effective option. Almost all patients experience significant pain relief, and some have improved range of motion. Joint loosening and infection are potential late complications in prosthetic joints but are uncommon.
- 2019 ACR/AF Practice Guidelines: Osteoarthritis of the Hand, Knee, and Hip
Viral Hepatitis C: Epidemiology, Pathogenesis, Transmission, And Natural History
- Changing incidence and prevalence of HCV
- Increasing burden of HCV-related liver disease
Introduction to the Patient with Rheumatic Disease
- ACR/SAA/SRTN 2015 Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis.
- American College of Rheumatology 2012 Recommendations for the Use of Nonpharmacologic and Pharmacologic Therapies in Osteoarthritis of the Hand, Hip, and Knee
.png)
