- Nonpharmacologic measures that have the potential to improve outcomes in osteoarthritis include patient education, physical and occupational therapy assessment and interventions, exercise, weight loss, and dietary measures.
- Therapies with potential to prevent or retard the progression of articular cartilage breakdown have received a great deal of attention in recent years, including tetracyclines, protease inhibitors, antiresorptive agents (i.e., bisphosphonates, calcitonin), glycosaminoglycan compounds, growth factors, and cytokine inhibitors.
- In patients with badly damaged knees and hips, total joint replacement is an effective option. Almost all patients experience significant pain relief, and some have improved range of motion. Joint loosening and infection are potential late complications in prosthetic joints but are uncommon.
Latest Updates
- Nonpharmacologic measures that have the potential to improve outcomes in osteoarthritis include patient education, physical and occupational therapy assessment and interventions, exercise, weight loss, and dietary measures.
- Therapies with potential to prevent or retard the progression of articular cartilage breakdown have received a great deal of attention in recent years, including tetracyclines, protease inhibitors, antiresorptive agents (i.e., bisphosphonates, calcitonin), glycosaminoglycan compounds, growth factors, and cytokine inhibitors.
- In patients with badly damaged knees and hips, total joint replacement is an effective option. Almost all patients experience significant pain relief, and some have improved range of motion. Joint loosening and infection are potential late complications in prosthetic joints but are uncommon.
- 2019 ACR/AF Practice Guidelines: Osteoarthritis of the Hand, Knee, and Hip
Viral Hepatitis C: Epidemiology, Pathogenesis, Transmission, And Natural History
- Changing incidence and prevalence of HCV
- Increasing burden of HCV-related liver disease
- Nonpharmacologic measures that have the potential to improve outcomes in osteoarthritis include patient education, physical and occupational therapy assessment and interventions, exercise, weight loss, and dietary measures.
- Therapies with potential to prevent or retard the progression of articular cartilage breakdown have received a great deal of attention in recent years, including tetracyclines, protease inhibitors, antiresorptive agents (i.e., bisphosphonates, calcitonin), glycosaminoglycan compounds, growth factors, and cytokine inhibitors.
- In patients with badly damaged knees and hips, total joint replacement is an effective option. Almost all patients experience significant pain relief, and some have improved range of motion. Joint loosening and infection are potential late complications in prosthetic joints but are uncommon.
- 2019 ACR/AF Practice Guidelines: Osteoarthritis of the Hand, Knee, and Hip
- Tenofovir alafenamide (AF) was FDA approved in November 2016 for the treatment of chronic hepatitis B. It has enhanced plasma stability and more efficient delivery to the hepatocytes with a lower dose compared with tenofovir disoproxil fumarate (DF). Tenofovir AF has similar efficacy to tenofovir DF but less nephrotoxicity (smaller increase in serum Cr and median changes in estimated GFR) and bone toxicity (smaller mean percentage decrease from baseline hip and spine bone mineral density).
- Major advances in basic research in hepatitis B are paving the way for the identification of new therapeutic targets with the goal of complete cure with physical elimination of cccDNA.
- Postmarketing studies have demonstrated a risk of HBV reactivation during treatment with hepatitis C direct antiviral agents, and it is recommended to monitor patients with HBV-HCV coinfection with serial lab tests and consider concomitant HBV treatment analogue for patients who meet the standard criteria for HBV treatment.
- Several safe and effective vaccines exist to prevent hepatitis A infections.
- Significant morbidity continues to occur in the United States among international travelers, injection drug users, and persons with underlying liver disease.
- In developing countries, the epidemiologic transition has increased the prevalence of clinically severe hepatitis A infections.
- Several safe and effective vaccines exist to prevent hepatitis A infections.
- Significant morbidity continues to occur in the United States among international travelers, injection drug users, and persons with underlying liver disease.
- In developing countries, the epidemiologic transition has increased the prevalence of clinically severe hepatitis A infections.
Introduction to the Patient with Rheumatic Disease
- ACR/SAA/SRTN 2015 Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis.
- American College of Rheumatology 2012 Recommendations for the Use of Nonpharmacologic and Pharmacologic Therapies in Osteoarthritis of the Hand, Hip, and Knee
