What's New | Decker

Novel therapies with the potential for management of anaphylaxis are currently being investigated. Omalizumab, a monoclonal antibody, has several proposed mechanisms of action, among which includes the rapid reduction of the level of free immunoglobulin E (IgE) in serum. Omalizumab has been approved and used in the treatment of patients with moderate to severe asthma as well as other IgE-mediated allergic disorders. Although there have been case reports regarding its use in anaphylaxis, ongoing research is needs to be performed.
Another potential therapy for anaphylaxis is methylene blue. It has been show to inhibit the relaxation of smooth muscle in vessels that lead to vasodilation and shock. Animal studies have demonstrated the potential of methylene blue in the prevention of cerebral ischemia associated with anaphylactic shock; however, more research is needed.

Anne E. Dixon, MA, BMBCH, Kohei Hasegawa, MD, MPH, Haitham Nsour, MBBS

ATS guidelines for exercise-induced bronchoconstriction, asthma in the elderly, and asthma in the workplace
ERS/ATS guideline for severe asthma discusses pharmacologic modalities of asthma management and bronchial thermoplasty.
2020 GINA practice guidelines no longer recommend treatment with SABA alone, without inhaled ICS. Recommend that all adults and adolescents with asthma should receive ICS-containing controller treatment.
2020 NAEPP practice guidelines delineating optimal treatment steps in adolescents and adults with asthma. This includes bronchial thermoplasty and immunotherapy.

The chief presenting complaint in acute pancreatitis is abdominal pain. The differential diagnosis for pancreatitis is broad, and includes abdominal, pulmonary, urologic and cardiovascular pathologies.
Recent guidelines state that the diagnosis of acute pancreatitis should be established by meeting two of the following clinical, laboratory, or imaging criteria: abdominal pain and examination consistent with the disease, a serum amylase and/or lipase three times the upper limit of normal, and/or computed tomography, magnetic resonance imaging, or ultrasonography findings consistent with the disease.

Beta blockers remain underused in clinical practice despite demonstrated efficacy in acute myocardial infarction (AMI). They have been shown to reduce myocardial oxygen demand and infarction size, and alleviate AMI-related pain. They also reduce the likelihood of developing mechanical and arrhythmogenic complications of AMI. They can be dosed in a wide range, and should be started at the lower end of the dosing range and titrated upward. The only relative contraindications to treatment with beta blockers are mild to moderate heart failure, obstructive airway disease (in the absence of asthma), peripheral vascular disease, diabetes mellitus and a history of cardiomyopathy.

Stuart L Linas, MD, FACP

Curtis Wittmann, MD

A patient with posttraumatic stress disorder (PTSD) is more likely to initially present for treatment in a medical, rather than mental health, setting; however, primary care physicians recognize symptoms of PTSD in these patients only approximately 50% of the time, and often do not make the diagnosis. Patients presenting to the emergency department for physical trauma are at risk, as are combat veterans and victims of rape or domestic violence. In addition, patients undergoing frightening, painful or life-threatening medical illnesses or procedures may develop PTSD. The provision of support and information about PTSD to patients in the emergency department may enable early recognition of the symptoms and may prevent the development of full-blown PTSD.

New definitions of hypertension have been established. Normal blood pressure is SBP < 120 mm Hg and DBP < 80 mm Hg. Elevated blood pressure is defined as SBP 120-129 mm Hg and DBP < 80 mm Hg. Stage 1 hypertension is defined as SBP 130-139 mm Hg or DBP 80-89 mm Hg, and stage 2 hypertension is defined as SBP ≥ 140 mm Hg or DBP ≥ 90 mm Hg.
The ATACH-2 trial showed that intensive blood pressure lowering in patients with intracranial hemorrhage leads to increased adverse events without substantial benefit.
ENCHANTED study did not show benefit in intensive blood pressure reduction in patients with acute ischemic stroke who have received intravenous thrombolysis.

Bedside right lower quadrant ultrasonography to assess for acute appendicitis is rapid and noninvasive and does not involve ionizing radiation. Studies have validated that nonradiologist clinicians, when trained properly, can safely and accurately perform this examination, with sensitivities and specificities similar to those achieved by radiologists.
Ultrasonographic detection of either a complex fluid collection or abscess is reported to be 99% specific for diagnosis of a perforated appendix but only 36% sensitive.
A recent randomized controlled trial of amoxicillin-clavulanate versus appendectomy demonstrated the noninferiority of antibiotics for treatment of acute noncomplicated appendicitis but did not demonstrate an increased rate of complications in the appendectomy group. However, a Cochrane review of antibiotic therapy versus operative management did not find conclusive data to support antibiotic therapy and concluded that appendectomy remains the gold standard treatment.

Allergy and Immunology