Latest Updates

The Respiratory System: Physiologic Assessment and Real-world Application

    • Reflectance Pulse Oximetry: The use of backscattered light rather than transmitted light can be helpful in low-signal settings.
    • Improved Signal Processing for Pulse Oximetry: Proprietary algorithms and advances in signal processing have improved the precision of pulse oximetry.
    • Calorimetric Detection: Colorimetric CO2 detection can be used to ensure nasoenteric placement rather than respiratory placement.

The Respiratory System: Physiologic Assessment and Real-world Application

    • Reflectance Pulse Oximetry: The use of backscattered light rather than transmitted light can be helpful in low-signal settings.
    • Improved Signal Processing for Pulse Oximetry: Proprietary algorithms and advances in signal processing have improved the precision of pulse oximetry.
    • Calorimetric Detection: Colorimetric CO2 detection can be used to ensure nasoenteric placement rather than respiratory placement.

The Respiratory System: Physiologic Assessment and Real-world Application

    • Reflectance Pulse Oximetry: The use of backscattered light rather than transmitted light can be helpful in low-signal settings.
    • Improved Signal Processing for Pulse Oximetry: Proprietary algorithms and advances in signal processing have improved the precision of pulse oximetry.
    • Calorimetric Detection: Colorimetric CO2 detection can be used to ensure nasoenteric placement rather than respiratory placement.

Primary Hyperparathyroidism

    • Parathyroidectomy is indicated for symptomatic primary hyperparathyroidism or asymptomatic primary hyperparathyroidism when medical surveillance is not possible or desired.
    • Preoperative imaging is necessary for preoperative planning if minimally invasive parathyroidectomy is planned. Imaging may include sestamibi scan, ultrasonography, and four-dimensional CT.
    • Total parathyroidectomy with autotransplant or 3.5-gland parathyroidectomy is recommended in the setting of familial primary hyperparathyroidism such as multiple endocrine neoplasia.

Primary Hyperparathyroidism

    • Parathyroidectomy is indicated for symptomatic primary hyperparathyroidism or asymptomatic primary hyperparathyroidism when medical surveillance is not possible or desired.
    • Preoperative imaging is necessary for preoperative planning if minimally invasive parathyroidectomy is planned. Imaging may include sestamibi scan, ultrasonography, and four-dimensional CT.
    • Total parathyroidectomy with autotransplant or 3.5-gland parathyroidectomy is recommended in the setting of familial primary hyperparathyroidism such as multiple endocrine neoplasia.

Nerve Sheath Tumors: Malignant peripheral nerve sheath tumors, Schwannomas, and Neurofibromas

    • Oncogenic signatures responsible for the transformation MPNST include activation of the STAT3/HIF, catenin/Wnt and RHO/ROCK pathways.
    • MPNSTs often harbor recurrent inactivation of polycomb repressive complex 2 from somatic mutation of EED and/or SUZ12.
    • Genetic analysis revealed germline mutations in SMARCB1 in approximately 50% of individuals affected by familial schwannomatosis.
    • Germline mutations in LZTR1 were identified in about 80% of schwannomatosis cases lacking mutations in SMARCB1.

Tertiary Hyperparathyroidism

    • Tertiary hyperparathyroidism is the persistence of hyperparathyroidism initially secondary to renal failure after a patient has had renal transplantation.
    • Parathyroidectomy is recommended to obtain normal serum calcium in tertiary hyperparathyroidism.
    • Tertiary hyperparathyroidism may present with a single adenoma, multiple adenomas, or four-gland hyperplasia. Limited resection of affected glands in case of single or double adenomas may be appropriate, although higher recurrence rates are reported.

Tertiary Hyperparathyroidism

    • Tertiary hyperparathyroidism is the persistence of hyperparathyroidism initially secondary to renal failure after a patient has had renal transplantation.
    • Parathyroidectomy is recommended to obtain normal serum calcium in tertiary hyperparathyroidism.
    • Tertiary hyperparathyroidism may present with a single adenoma, multiple adenomas, or four-gland hyperplasia. Limited resection of affected glands in case of single or double adenomas may be appropriate, although higher recurrence rates are reported.
« Previous | Next »
Updates per yearSpecialty updatesNumber of sections