Latest Updates

Liposarcoma

Joseph G Crompton, MD, PhD, Sarah M Dry, MD, Fritz C Eilber, MD, Arun S Singh, MD
    • Limb-sparing surgery with radiation for extremity soft tissue sarcoma is not inferior to amputation in outcome of disease-specific mortality.
    • Completeness of resection (R0, R1, R2) of retroperitoneal soft tissue sarcoma correlates with patient survival.
    • Emerging molecular characterization of subtypes of liposarcoma has provided novel therapeutic targets, such as CDK4 inhibitors.

Headache

Benjamin W Friedman, MD, MS
    • Targeting calcitonin gene related peptide can improve migraine pain
    • Greater occipital nerve blocks may alleviate migraine acutely
    • Clinical decision rules can be used to exclude subarachnoid hemorrhage

Local Treatment in the Management of Oligometastatic Prostate Cancer

Christopher P Evans, MD, Derya Tilki, MD
    • Retrospective studies report a survival benefit for local treatment in metastatic prostate cancer (mPCa) patients.
    • First data from a randomized trial does not show a survival benefit for the addition of external beam radiotherapy to androgen deprivation treatment in mPCa.
    • Local tumor treatment in patients with mPCa should only be offered within trials.

Liposarcoma

Joseph G Crompton, MD, PhD, Sarah M Dry, MD, Fritz C Eilber, MD, Arun S Singh, MD
    • Limb-sparing surgery with radiation for extremity soft tissue sarcoma is not inferior to amputation in outcome of disease-specific mortality.
    • Completeness of resection (R0, R1, R2) of retroperitoneal soft tissue sarcoma correlates with patient survival.
    • Emerging molecular characterization of subtypes of liposarcoma has provided novel therapeutic targets, such as CDK4 inhibitors.

Benign Tumors of the Spleen

Brandon Chapman, MD, Alessandro Paniccia, MD
    • Laparoscopic approach to splenectomy
    • Frequent incidental finding with increased use of imaging

Coma and Disorders of Consciousness

Nicole M Dubosh, MD, Jonathan A. Edlow, MD, FACEP
    • Non-convulsive status epilepticus is an important cause of coma that requires EEG for diagnosis.
    • Basilar artery stroke is a treatable cause of altered mentation
    • Physicians should actively seek to identify treatable structural or metabolic causes of coma

Coma and Disorders of Consciousness

Nicole M Dubosh, MD, Jonathan A. Edlow, MD, FACEP
    • Non-convulsive status epilepticus is an important cause of coma that requires EEG for diagnosis.
    • Basilar artery stroke is a treatable cause of altered mentation
    • Physicians should actively seek to identify treatable structural or metabolic causes of coma

Benign Tumors of the Spleen

Brandon Chapman, MD, Alessandro Paniccia, MD
    • Laparoscopic approach to splenectomy
    • Frequent incidental finding with increased use of imaging
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